girl applying cream to skin

Skin health and dietary sugars

This content has been reviewed by Anna Daniels, Registered Dietitian and Spokesperson of the British Dietetic Association.

Skin health and dietary sugars

The skin is the largest organ in the human body. Skin is the body’s first layer of defence and a key organ of our immune system, protecting the body from the external environment. Skin is important for the production of vitamin D, which is essential for healthy bones. Skin can also be an indicator of overall health (for example, skin rashes can be a sign of infection).

This article focuses on skin aging and on acne.

Skin aging

Most people are born with healthy, supple skin. Over time, as part of aging, our bodies have a harder time repairing skin damage and maintaining the skin’s elasticity. Skin aging is different for every individual. The complex process is not only influenced by internal factors (such as genetics) and number of years of aging, but also by external environmental factors, especially ultraviolet radiation (sun exposure) (1,2). Factors which influence skin aging include (2-4):


•    Genetics
•    Hormonal changes
•    Inflammation
•    UV radiation 
•    Smoking
•    Diet & lifestyle (including physical activity, alcohol and sleep)
•    Pollution 

Bearded man looking at wrinkes

Why do wrinkles form?

Collagen and elastin are essential proteins that provide structural integrity and elasticity to the skin. As we age, natural production of these proteins declines, and damage accumulates due to various factors (including those above). This results in decreased skin elasticity and wrinkle formation (3).

Reduced skin elasticity

The processes which lead to collagen and elastin breakdown, and loss of function, can include (3);

  • Age-related decrease in the production of collagen and elastin, and reduced repair of skin cells.
  • Increase in the enzymes responsible for the breakdown collagen and elastin (enzymes are substances in our bodies which speed up the chemical reactions that take place in the body).
  • Formation of advanced glycated end products which can cross-link collagen fibres, making them stiff and less elastic.
  • Damage from chronic inflammation.
Slices of rainbow coloured cake

Can sugars in the diet cause wrinkles?

There is no convincing evidence that consuming sugars causes the appearance of wrinkles. Some observational studies that have investigated the relationship between skin aging and diet quality have found that a healthy diet (e.g., diets rich in whole foods and nutrients) may be associated with fewer wrinkles [e.g., (5,6)]. Whilst a healthy balanced diet is important for overall health of the skin, these studies cannot demonstrate that diet is specifically protective against wrinkles (i.e., these studies cannot demonstrate causation, where one thing causes another to happen). Other factors (such as genetics and health-conscious behaviours of study participants, such as not smoking and good sun protection) may also influence the results (5,7).

Advanced glycated end products

Advanced glycated end products is the name given to proteins or fats that have become glycated (joined together with a carbohydrate-derived molecule). Advanced glycated end products can form in all the body’s cells and while this is a natural part of aging, excessive advanced glycated end products accumulation can impair skin elasticity and accelerate visible signs of aging (3). 

Media narratives often overstate the role of dietary sugars in skin glycation. While carbohydrate-derived molecules play a role in glycation, there is no evidence to suggest that, in healthy individuals, dietary sugars (which are not equivalent to the levels of glucose which circulates in our blood) cause an increase in skin wrinkles. Blood glucose is tightly regulated as our bodies need a constant supply to function normally. In healthy individuals, small peaks and troughs in blood glucose (e.g., from eating a meal or fasting overnight) are kept within a normal healthy range by the action of hormones.   

measuring blood sugar levels

What affect does blood glucose have on wrinkles?

A link has been found between prolonged hyperglycaemia (an abnormally high blood glucose level) and elevated advanced glycated end products (8,9). A key misunderstanding in skin health discussions is equating dietary sugar directly with blood glucose levels. In reality, blood glucose is regulated by insulin and other hormones to maintain homeostasis—even after carbohydrate consumption (10,11). Only in the case of prolonged hyperglycemia, such as in uncontrolled diabetes, do blood glucose levels remain chronically high (8) —which may contribute to elevated advanced glycated end products, potentially accelerating skin aging (9,12) However, more research is needed to understand the relationship between diabetes, advanced glycated end products and skin wrinkles. For healthy individuals, small, temporary increases in glucose from meals does not appear to pose the same risk (13,14).

What do the experts say?

To date, no independent national or international advisory body or scientific research organisation [such as the European Food Safety Authority (EFSA), the US Food and Drug Administration or National Institute on Aging] has drawn the conclusion that sugars cause wrinkles or skin aging. Indeed, skin care experts around the world agree that it is our age, genetics, and exposure to factors such as sunlight and smoking that have the greatest influence on skin aging (1–3,8). 


 

Acne

Acne is one of the most common skin conditions globally and often develops in adolescence and early adulthood due to the hormonal changes (15). Acne occurs when tiny holes in the skin, known as hair follicles, become blocked. These blockages cause spots, oily skin and sometimes skin that's hot or painful to touch. Acne most commonly develops on the face but can also develop on the back and chest (16).

There are four key factors that play a role in the development of acne (15):

  • Excess sebum (oil produced by the glands in the skin) which is driven by hormones.
  • Changes in the activity of the usually harmless Cutibacterium acnes skin bacteria. 
  • The cells of the skin follicles not shedding normally onto the skin's surface. 
  • Inflammation.
young girl touching her face

What causes acne?

The causes of acne are still not fully understood and there are many myths and misconceptions about the condition (16). Acne is thought to most commonly occur due to the changes in hormone levels, particularly during puberty. There is evidence that genetics may influence the likelihood of acne. However, the difference in the number of people affected by acne in westernised vs. non-westernised societies suggests that environmental factors are also responsible. Due to the complex nature of acne, a simple explanation of acne being ‘caused by’ any single environmental factor is unlikely.

Factors which may play a role in acne

The following factors have been suggested to play a role in acne (17):

  • Genetics
  • Hormones  
  • The skin and gut microbiome 
  • Stress
  • Air pollutants
  • Aggressive facial products
  • Certain medications 
  • Diet & lifestyle

Can certain carbohydrates in the diet cause acne?

The link between nutrition and acne has been extensively deliberated for many years and it is still unclear what influence diet may have on acne occurrence. The evidence for a link between diet and acne mainly comes from observational studies where causation (that one thing causes another to happen) is hard to establish. Though widely debated, evidence linking high-glycaemic-index (GI) diets and acne is starting to appear. Limited observational and clinical studies have noted associations or improvements in acne symptoms when individuals consume a low-GI or low glycaemic load (GL) diet (15,18). However, evidence is conflicting and mainly of low quality (19-21).

GI represents how quickly a food affects blood glucose levels when that food is eaten on its own. Carbohydrate foods that are broken down quickly by the body, and that cause a faster increase in blood glucose, have a high GI rating. For example, foods such as white bread, boiled potatoes and white rice have a high GI, while lower GI foods include wholegrain foods, most fruits and vegetables, beans, and lentils. Sugar itself has a medium GI. GL is a measure that considers the amount of carbohydrate in a portion of food together with how quickly it raises blood glucose levels (GI). As previously mentioned, blood glucose levels are tightly regulated and the small, short-lived peaks in blood glucose that follow eating carbohydrate-rich foods are part of a normal physiological process (22). Lower GI/GL diets are hypothesised to beneficially affect some of the hormones thought to play a role in the development of acne, although further research to fully understand potential mechanisms is needed (15). Nevertheless, for a healthy, balanced diet, it is important not to only focus on GI/GL, as not all low-GI/GL foods are healthy choices (some low-GI/GL foods, such as high-fat desserts or snacks, are high in saturated fat but low in vitamins and minerals (23). Carbohydrates alone (including sugars) should not be considered in isolation—overall dietary patterns are likely to matter more. 

Therefore, current dietary guidelines do not universally recommend low-GI/GL diets but rather focus on balanced eating patterns with an emphasis on whole grains, lean protein, oily fish, fruits and vegetables.

Ask the expert

What do the experts say?

Sugars and some sugars-containing foods, such as chocolate and sugars-sweetened beverages, are sometimes linked to the development of acne by the popular media. However, the evidence to support this is lacking. There is insufficient evidence to suggest that reducing or removing sugars from the diet leads to a reduction in acne. Indeed, the UK National Institute for Health Care Excellence, the British Association of Dermatologists, and the American Academy of Dermatology, agree diet is not currently considered a primary treatment for acne, and evidence for specific dietary interventions remains insufficient (19-21). Further research is needed to understand the complex nature of acne and the many genetic, hormonal and environmental factors that play a role in its development.

There is no conclusive evidence that dietary sugars directly cause wrinkles or acne. For optimal skin health, experts continue to recommend a healthy, balanced, nutrient-rich diet (with emphasis on whole foods rich in vitamins and minerals), adequate hydration and a healthy lifestyle —including sufficient sleep, lowering stress, good sun protection, lowering exposure to air pollution and not smoking (3,24,25).

References

  1. Zhang M, Lin Y, Han Z, Huang X, Zhou S, Wang S, et al. Exploring mechanisms of skin aging: insights for clinical treatment. Front Immunol. 2024;15:1421858. 
  2. Tobin DJ. Introduction to skin aging. Journal of Tissue Viability. 2017 Feb 1;26(1):37–46. 
  3. Hussein RS, Bin Dayel S, Abahussein O, El-Sherbiny AA. Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights. J Cosmet Dermatol. 2024 Nov 27;e16688. 
  4. Makrantonaki E, Zouboulis CC. Molecular Mechanisms of Skin Aging. Annals of the New York Academy of Sciences. 2007;1119(1):40–50. 
  5. Mekić S, Jacobs LC, Hamer MA, Ikram MA, Schoufour JD, Gunn DA, et al. A healthy diet in women is associated with less facial wrinkles in a large Dutch population-based cohort. J Am Acad Dermatol. 2019 May;80(5):1358-1363.e2. 
  6. Cosgrove MC, Franco OH, Granger SP, Murray PG, Mayes AE. Dietary nutrient intakes and skin-aging appearance among middle-aged American women23. The American Journal of Clinical Nutrition. 2007 Oct 1;86(4):1225–31. 
  7. Ekiz Ö, Yüce G, Ulaşli SS, Ekiz F, Yüce S, Başar Ö. Factors influencing skin ageing in a Mediterranean population from Turkey. Clinical and Experimental Dermatology. 2012 Jul 1;37(5):492–6. 
  8. Chaudhuri J, Bains Y, Guha S, Kahn A, Hall D, Bose N, et al. The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality. Cell Metab. 2018 Sep 4;28(3):337–52. 
  9. Chen C yu, Zhang JQ, Li L, Guo M miao, He Y fan, Dong Y mao, et al. Advanced Glycation End Products in the Skin: Molecular Mechanisms, Methods of Measurement, and Inhibitory Pathways. Front Med (Lausanne). 2022 May 11;9:837222. 
  10. Hamer MA, Pardo LM, Jacobs LC, Ikram MA, Laven JS, Kayser M, et al. Lifestyle and Physiological Factors Associated with Facial Wrinkling in Men and Women. Journal of Investigative Dermatology. 2017 Aug 1;137(8):1692–9. 
  11. Lean MEJ, Te Morenga L. Sugar and Type 2 diabetes. British Medical Bulletin. 2016 Dec 1;120(1):43–53. 
  12. Gkogkolou P, Böhm M. Advanced glycation end products: Key players in skin aging? Dermatoendocrinol. 2012 Jul 1;4(3):259–70. 
  13. Żelaźniewicz A, Nowak-Kornicka J, Osochocka A, Pawłowski B. Perceived facial age and biochemical indicators of glycemia in adult men and women. Sci Rep. 2022 Jun 16;12(1):10149. 
  14. Christidis G, Küppers F, Karatayli SC, Karatayli E, Weber SN, Lammert F, et al. Skin advanced glycation end-products as indicators of the metabolic profile in diabetes mellitus: correlations with glycemic control, liver phenotypes and metabolic biomarkers. BMC Endocr Disord. 2024 Mar 5;24(1):31. 
  15. Baldwin H, Tan J. Effects of Diet on Acne and Its Response to Treatment. Am J Clin Dermatol. 2021;22(1):55–65. 
  16. National Health Service (NHS). 2017. Acne. https://www.nhs.uk/conditions/acne/
  17. Ryguła I, Pikiewicz W, Kaminiów K. Impact of Diet and Nutrition in Patients with Acne Vulgaris. Nutrients. 2024 May 14;16(10):1476. 
  18. Meixiong J, Ricco C, Vasavda C, Ho BK. Diet and acne: A systematic review. JAAD International. 2022 Jun 1;7:95–112. 
  19. Chaplin S. NICE guidance on the management of acne vulgaris. Prescriber. 2021;32(11–12):15–7. 
  20. Reynolds RV, Yeung H, Cheng CE, Cook-Bolden F, Desai SR, Druby KM, et al. Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology. 2024 May 1;90(5):1006.e1-1006.e30. 
  21. British Association of Dermatologists. Acne. https://www.bad.org.uk/pils/acne/
  22. Röder PV, Wu B, Liu Y, Han W. Pancreatic regulation of glucose homeostasis. Exp Mol Med. 2016 Mar;48(3):e219–e219. 
  23. Diabetes UK. Glycaemic index and diabetes. https://www.diabetes.org.uk/living-with-diabetes/eating/carbohydrates-and-diabetes/glycaemic-index-and-diabetes
  24. Solway J, McBride M, Haq F, Abdul W, Miller R. Diet and Dermatology: The Role of a Whole-food, Plant-based Diet in Preventing and Reversing Skin Aging-A Review. J Clin Aesthet Dermatol. 2020 May;13(5):38–43. 
  25. Wong QYA, Chew FT. Defining skin aging and its risk factors: a systematic review and meta-analysis. Sci Rep. 2021 Nov 11;11(1):22075.